Methamphetamine/Crystal Meth/T: (extract)
In low doses, methamphetamine can elevate mood, increase alertness, concentration and energy in fatigued individuals, reduce appetite and promote (initial) weight loss. At higher doses, it can induce psychosis, breakdown of skeletal muscle, seizures and bleeding in the brain. Chronic high-dose use can precipitate unpredictable and rapid mood swings, prominent delusions, violent behavior and erectile dysfunction.
Recreationally, methamphetamine’s ability to increase energy has been reported to lift mood and increase sexual desire to such an extent that users are able to engage in limited sexual activity continuously for several days. Methamphetamine is known to have a high addiction liability (i.e. compulsive methamphetamine use) and dependence liability (i.e. withdrawal symptoms occur when methamphetamine use ceases).
Heavy recreational use of methamphetamine may lead to a post-acute-withdrawal syndrome, which can persist for months beyond the typical withdrawal period. Methamphetamine is neurotoxic to human mid-brain dopaminergic neurons. It has also been shown to damage serotonin neurons in the central nervous system. This damage includes adverse changes in brain structure and function, such as reductions in grey matter volume in several brain regions and adverse changes in markers of metabolic integrity.